Drivers found part of Ormskirk covered in police tape on Saturday morning.
Roads around the Civic Centre were closed as police started their investigations.
A Lancashire Police spokesperson said : “We were called at 02:45 hours on Saturday 28th April to reports of an assault outside the Horse Shoe Inn on Southport Road, Ormskirk.
“Two men – one is his 20s and the other in his 30s – were taken to hospital to be treated for stab wounds. Their conditions are described as serious but stable.
“Enquiries are ongoing and anyone with information is asked to call Ormskirk CID on 01695566112, or failing that, 101, quoting log number 169 of 28th April